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Substitute new_ placeholder in the second line with your new prefix. Run it: http://www.yoursite.com/rename.php and wait until it responds with an OK, usually after a couple of seconds. Delete the rename.php script. Edit the configuration.php file and find the line starting with var $dbprefix. It should look like this: var $dbprefix = \'jos_\'; Replace the old jos_ prefix with new prefix, i.e. the one used in the second line of your rename.php script.
URL: http://magazine.joomla.org/topics/item/108-the-prefix-has-nothing-to-do-with-telephony