/* HOME PAGE CUSTOM TEMPLATE */

function home_pagecustom() {
/* check to see if homepage. has to happen inside the function */
if (is_home() || is_front_page())  {
?>
...Your custom layout goes here...
<?php } }

/* Now we tell Thesis to use the home page custom template */

remove_action('thesis_hook_custom_template', 'thesis_custom_template_sample');
add_action('thesis_hook_custom_template', 'home_pagecustom');

http://www.berchman.com/thesis-tutorial-multiple-custom-page-templates/#primer

In this Thesis WP tutorial for multiple custom page templates, we find code for making a custom homepage template as well.

Homepage Custom Template Thesis WP

wordpress

PHP