import sys
from PyQt4.QtGui import *
import comtypes.client

class LayerSetsExporter(QWidget):

    def __init__(self, parent = None):
        super(LayerSetsExporter, self).__init__(parent)
        self.createLayout()
        self.createConnection()

    def setLayerSetsVisible(self, layerSets, state):
        for layerSet in layerSets:
            layerSet.visible = False

    def processRun(self):
        outputPath = 'D:/Python/Temp/'

        app = comtypes.client.CreateObject('Photoshop.Application')
        doc = app.activeDocument

        optionJpg = comtypes.client.CreateObject('Photoshop.JPEGSaveOptions')
        optionJpg.quality = 8

        count = 0
        layerSets = doc.layerSets
        for layerSet in layerSets:
            self.setLayerSetsVisible(layerSets, False)
            layerSet.visible = True
            doc.saveAs(outputPath + str(count) + '.jpg', optionJpg, True)
            count += 1

    def createLayout(self):
        self.btnRun = QPushButton('&Run')
        layout = QVBoxLayout()
        layout.addWidget(self.btnRun)

        self.resize(200,100)
        self.setWindowTitle('PS LayerSets Exporter')
        self.setLayout(layout)

    def createConnection(self):
        self.btnRun.clicked.connect(self.processRun)

qApp = QApplication(sys.argv)

exporter = LayerSetsExporter()
exporter.show()

qApp.exec_()

import sys
from PyQt4.QtGui import *
import comtypes.client

class LayerSetsExporter(QWidget):

    def __init__(self, parent = None):
        super(LayerSetsExporter, self).__init__(parent)
        self.createLayout()
        self.createConnection()

    def setLayerSetsVisible(self, layerSets, state):
        for layerSet in layerSets:
            layerSet.visible = False

    def processRun(self):
        outputPath = 'D:/Python/Temp/'

        app = comtypes.client.CreateObject('Photoshop.Application')
        doc = app.activeDocument

        optionJpg = comtypes.client.CreateObject('Photoshop.JPEGSaveOptions')
        optionJpg.quality = 8

        count = 0
        layerSets = doc.layerSets
        for layerSet in layerSets:
            self.setLayerSetsVisible(layerSet, False)
            layerSet.visible = True
            doc.saveAs(outputPath + str(count) + '.jpg', optionJpg, True)
            count += 1

    def createLayout(self):
        self.btnRun = QPushButton('&Run')
        layout = QVBoxLayout()
        layout.addWidget(self.btnRun)

        self.resize(200,100)
        self.setWindowTitle('PS LayerSets Exporter')
        self.setLayout(layout)

    def createConnection(self):
        self.btnRun.clicked.connect(self.processRun)

qApp = QApplication(sys.argv)

exporter = LayerSetsExporter()
exporter.show()

qApp.exec_()

Photoshop python script
export multiple files with each layerSet

Export JPEG Files with each LayerSet (Photoshop Python with PyQt)

python

Python