/ Published in: VB.NET
                    
                                        
                            
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//logic to identify your update panel Id if there are multiple update panels on your page.
If scriptManager.AsyncPostBackSourceElementID.Equals(upUser.UniqueID) Or
//logic to identify your the control that generated this post back.
scriptManager.AsyncPostBackSourceElementID.Equals(cmdFilterUser.UniqueID) Or
//if you want to identify a specific element exist in this panel like in my case there is gridview naming "ngvAuditHistory"
scriptManager.AsyncPostBackSourceElementID.Contains("ngvAuditHistory")
Then
If Request.Params("__EVENTARGUMENT") = "0" Then
//your logic for the __dopostback response
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